Consequent to some food-borne incidents in recent years, there have been significant increase in public health concern and decrease in consumer confidence. Despite significant advances in detection tools, regulations, monitoring and consumer education on food safety, reports of food borne illness outbreaks continue to increase. Within the supply chain which is increasingly becoming more complex in the globalized market, adulteration (unintentional or intentional) is the key food safety issue. Increase in imports of food/processed food items due to cost concerns, availability and consumer demand for diverse food products also provide chances for food contamination/adulteration. Regulatory bodies are comforting with major food safety issues including changes in our food production and supply, environmental changes leading to food contamination, new and emerging bacteria, toxins, and antibiotic resistance and consumer preferences and habits leading to increase in imported foods. At this juncture, what should be the effective strategies to address the emerging challenges to provide safe, healthy, nutritious and sustainable produced food to the world's population?