Someone was taking Daflon 500 mg (450 mg Diosmin, 50 mg Hesperidin) twice daily for her varicose veins. Now, the manufacturer makes Daflon 1000 mg (900 mg Diosmin, 100 mg Hesperidin).
Now, the Q is, if she takes the new dosage form 1000 mg once daily, will this dose be equivalent to 500 mg once daily or the pharmacokinetics and the therapeutic effects will be different?
based on a double-blind, multicenter, RCT comparing 1,000 mg tabs vs 500 mg tabs (same daily dose) in acute hemorrhoid, the authors concluded that "We have been demonstrated that the new single MPFF 1000 mg tablet has clinical acceptability and a good safety profile, comparable to that of MPFF 500 mg tablets. MPFF 1000 mg was as effective as MPFF 500 mg in reducing anal pain and bleeding. The new dose regimen should lead to better treatment adherence and consequently to better management of hemorrhoidal disease."
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Of course it will be different in therapeutic effect, since the dose are higher. But the Question is, did The Varicose patients had done the Definitive Treatment such as EndoVenous Laser/Radiofrequency/Stripping Varicose veins first? or Not yet...
For Us in https://www.varisesindonesia.id following Guidelines Recommendation, use MPFF for additional regiments (Complement) but Not the Main therapy.
For researchers, Best Discuss Varicose veins not Hemorrhoid, be Relevantly evidence please.
Jefry Winner G
Why you don't recommend the 1000 mg dose regimen? Is there any study that supports your view?
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