I could not synthesize Selenium nanoparticles by PEG 200 at up-scale ( more than 100 ml) as it got aggregated while at small amounts it works fine , I work with 850 PPM using selenium powder in PEG 200 heated to around 200 degree. What is the problem?
Nabodita Sinha
Amr Mahmoud Scale-up of nanoparticles needs optimization as most nanoparticle synthesis is easy at small amounts. In this case, I would suggest using a higher concentration or molecular weight of PEG. The following article might be of some help to you. " Challenges posed by the scale-up of nanomedicines " DOI: 10.2217/nnm.12.3
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