Salt formation of weak acid causes ionization of drug due to which solubility increase but we have studied drug absorbed in unionized form then how salt formation will improve the absorption of a drug?
The micronization and salt formation of the crystalline compound of molecule enhance the surface area. This overcome the challenges of the molecule solubilization in particular solvent. This can enhance the rate of dissolution of the drug
The formation of salts from weak acids can increase drug solubility for several reasons. One of the most common reasons is the ionization of the weak acid in solution, which increases the solubility of the drug through the creation of charged species. This is because charged species are more soluble in aqueous environments than uncharged species, and the ionization of the weak acid increases the concentration of charged species in the solution.
In addition, the formation of a salt can change the pH of the solution, which can also impact drug solubility. For example, if the salt is formed from a weak acid that has a pKa value close to the pH of the solution, the formation of the salt can shift the pH of the solution to a more basic or acidic value, which can increase the solubility of the drug.
Finally, the formation of a salt can also impact the stability of the drug in solution. For example, the salt can increase the stability of the drug by preventing its precipitation or by preventing oxidation or other chemical reactions.
Thank you for your answer. But sir you are saying salt formation favors tha ionisation which increases the solubility but sir ionized drug can not be absorbed so how can salt formation will lead to increase in bioavailability? @ Muhammad zohaib safdar
The micronization and salt formation of the crystalline compound of molecule enhance the surface area. This overcome the challenges of the molecule solubilization in particular solvent. This can enhance the rate of dissolution of the drug.
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