Dear companions, this week i have been reading an article wich explains the etiopathogenesis of status epiletpicus, the doi for that article is 10.1111/vec.12605, in this paper, there`s explained the neurone regulation and the mechanism wich fails in control the normal electric activity when a convulsion lead to SE, even if those mechanisms are still unknown.
That made me realize about ketamine as NMDA antagonist which lead to calcium and sodium channels blockade, also have an activity lowering the releasing of glutamate wich is excitatory in the central nervous sistem.
So can it mean that using ketamine could put a brake in the expansion of the epileptic focuses by controling the ion fluxes?
Also i found interesting the rol of the efflux of potassium in the despolarization. For that cause i also wanted to know if putting insuline could help with the control of SE patient in the first phase when there is also hiperglycemia.
Greetings and thanks in advance.
Thank you very much for your response, but in my humble opinion, I consider it more important to stop the epileptic activity than to have some undesired effects of the medication to prevent the brain tissue from suffering more damage and in cases where the status is refractory to the usual medication, It seems an interesting option because there is an article at least where the control of epileptic activity was determined by electroencephalography.
In my model- adding more ketamine to a patient in status should make the seizure activity worse and further endanger the subject. Years ago I observed a patient having an epileptic seizure, induced by ketamine, go into status when given an additional dose of ketamine.
I have found this article:Article Ketamine controls prolonged status epilepticus
. Where they introduce the idea of that the ketamina is not effective to the beginning of the epileptic status, but that if when it goes a time, the problem is that there is no a strong correlation between dose - effect, but if that notice the neuroprotective properties and hemodinamical stability.- Badges
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