The ras genes appear to be finely alanced at the edge of oncogenesis. Almost any mutation at either position 12 or 61 can convert a c-ras proto-oncogene into an active oncogene. All C-ras genes have Glycine at position 12. If it is replaced in vitro by any other ofthe 19 amino acids except proline, the mutated c-ras gene can transform cultured cells.
Stephan P Tenbaum
@Yuriy "...turn of the chain" ... and results in a protein not able to induce hyperactivation of the pathway. It would be a loss of function protein.
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