Pseudorabies virus is a pathogen of swine, it do not infect primate and human. However, the HSV-1, belongs to the same family with PRV, can infect human.
Why does PRV do not infect human?
Is it the receptor? replication?..............
Thanks for your comments.
PRV is a DNA virus, maybe is more stable than Influenza virus.
the mutation of envelope proteins (gB?) will results into infection of primate?
what is the best condition for virus evolution?
In fact, i want to know the mechanism of PRV can not infect primate.
Very good question. Unfortunately, I do no know the exact answer and frankly, I am not sure who may.
A number of possibilities come to mind. First may be the absence of appropriate cell surface receptors. This is not very likely, because the PRV receptor HVeC also mediates entry of HSV-1, glycoprotein gD is required for entry of both viruses and HVeB can also mediate PRV entry, but sequence/structure differences of the procine vs human receptors cannot be excluded. Alternatively, the IE180 transactivator may not be equally functional in human cells, thereby potentially blocking effective replication. Also, the ability/mechanism of PRV to engage the IFN system may differ in human as compared to porcine cells, thereby defining the outcome of the infection.
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