I am transplanting a polymer (Parylene-C) coated structure in the anterior chamber of the eye and expect it to reside on the iris, however, almost all of them get adhered to the cornea and not the iris. Is there any eye-physiology-related explanation to that?
Perhaps this is due to the iris movements and uneven surface, unlike the cornea.
Thanks Vladimir Siplivy . We checked them 3 days after transplantation and they looked very much attached to the iris but when we came back to check them after 1 month, they were attached to the cornea. The only explanation I have is MAYBE the IOP increased and pushed it to the cornea.
I saw that there is a technique where they introduce a gas bubble to keep the implanted tissue layer (for cornea) pushed towards the cornea. Well we want the reverse. I wonder if there are some kind of bio glues that could be used to increase adhesion to the iris?
Your device will not hold the iris due to its mobility. The iris walks back and forth, folds on it change it's size, the pupil narrows and expands. For fixation on the iris, sutures or snap technique are used. For example, this is how the Artisan lense used to be fixed https://www.youtube.com/watch?v=F8p9_fJ-4mU