I am working on an investigational anti-HCC drug which seems to suppress the expression of pERK, pJNK in both HepG2 cells (in vitro) and DEN-induced HCC in rats (in vivo), but while this drug upregulates the expression of pp38 in HSC and HepG2 cells, it however suppresses the expression of pp38 in DEN-induced HCC in rats (in vivo).