Alex Boye

6 Questions 20 Answers 0 Followers

Questions related from Alex Boye

Why does an investigational drug upregulate pp38 in HepG2 cells in vitro but downregulate pp38 in vivo in DEN-induced HCC in a rat model?

I am working on an investigational anti-HCC drug which seems to suppress the expression of pERK, pJNK in both HepG2 cells (in vitro) and DEN-induced HCC in rats (in vivo), but while this drug...

22 April 2014 7,283 1 View

Is there an inhibitor for precursors of TGF-beta 1 biosynthesis? If yes, what are these precursors and their respective inhibitors?

Transforming growth factor beta 1 has become a 'necessary evil' giving its role in normal homeostatic processes and pathophysiological states such as cancer. Many studies have focused on its...

14 April 2014 6,432 1 View

Why does the biting pattern of infected anopheles mosquitoes coincide with the appearance of Plasmodium parasite in peripheral blood?

It is reported that the biting pattern of mosquitoes happens in a manner and time when plasmodium parasites are feeding on the host blood and the reason given is that that helps to transmit the...

04 March 2014 9,735 18 View

Why do normal mice offset their natural prey (cats) but Toxoplasma-infected mice develop aphobia towards cats?

Mammals such as cats and mice serve as intermediate host for Toxoplasma gondii, but unexplained reports indicate that mice who naturally offset cats lose that survival sense of urgency following...

04 March 2014 6,447 9 View

If bacteria use 'Quorum Sensing' to engage in intra-and-inter-species communication, how can we leverage on this phenomenon for antibiotics?

Different chemicals are produced by bacteria for inter and intra species communication, how do we use these chemicals to our advantage in developing antibiotics?

14 February 2014 6,943 13 View

Mechanism of sulfonamide drugs

Do sulfonamides mechanistically inhibit dihydropteroate synthetase OR they compete with para-aminobenzoic acid for the active site of the enzyme?

01 January 1970 411 3 View