Numerous papers have reported increased invasion of cancer cells after treatment with high doses of ionizing radiation. I have seen this in my work with lung cancer cells as well. Is there a common biological explanation for this observation or do different cell lines activate different pathways that increase invasion of the cells?
well to talk very generally ... I am thinking like due to radiation epigenetic modifications like DNA hyper or hypomethylation can happens which can silence or activate different developmental related genes and which in turn can activate or suppressed different pathways that may contribute to increase cell invasion.
It has been reported that radiation results in increased MMP-2 and -9 expression for a limited time period. I do not the detailed machinery in which IR causes the upregulation of MMP proteins (i.e. how transcription is activated?)
Whether ionizing irradiation augments or alleviates invasion depends on various factors (e.g., please see discussion in http://dx.doi.org/10.1016/j.semcancer.2015.09.003, from which PDF is freely downloadable).
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