Although, senescence and mitotic catastrophe are 2 independent processes, I have observed cells with enlarged appearance, highly polyunucleated and with micro-nuceli that stain positive for beta-galactosidase activity.
They are lung cancer cells, both EGFR mutant. One is p53 wt and the other is p53 mut. The MC was a response to ionizing radiation.
Very fascinating phenomenon, I think. . Mitotic catastrophe is defined as the failure to cell cycle arrest during the mitosis, which triggers the aberrant chromosome segregation. Further, SA-β-gal（senescence-associated beta-galactosidase) is not necessarily derived from cellular senescence, and this molecule is induced by cellular stress response. That is why caspase2-dependent stress response is likely the co-existence of mitotic catastrophe and SA-β-gal.
The simple answer is yes. Consequently, other criteria are needed to discriminate between the two processes.
I believe it can. The irradiation could affect different genes some of which may ellicit several responses or developments that may be easily misunderstood.
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