Hi everyone,
Alginate is a well-known marine-derived carbohydrate and has plenty of different application. However, its inflammatory response has restricted its in vivo application as gel or carrier. Could you please help me understand why alginate demonstrates inflammatory response and how we can decrease this limitation?
Polysaccharides are frequently a component of bacteria cellular wall, so they are recognized by human complement immunological system. Polysaccharides that are not recognized are: hyaluronic, heparin and glycogen, medium to low inflammatory are dextran, chitosan, alginate, cyclodextrines and starch, strong complement reaction is provoked by various lipopolisaccharides.
Additional problem may come from the residues of protein in the polysaccharide, try to remove any organic impurities (proteins and lipids).
using a crosslinking agent like Riboflavin, genipin can reduce the swelling to some extent. Since they have more hydrophilic ends attracting water molecules is more evident and water uptake is promoted depending on the molecular weight.
Dear Prof. Ciach
Great thanks for your response. Actually, there is a challenge on how alginate affords inflammatory. Some of scientists believe that the content of M and G blocks have a significant effect on their immunological response. Is this an intrinsic behavior? for example, alginate doesn't have a FDA approval for blood-contact applications.
Dear Saadi
You are right. But the crosslinking of alginate really helps it to decrease its immunological response?
- Badges
- Science topic
- Similar topics
- Mathematical Sciences
- Graphs