Concentration of protease inhibitor (cystatin) increases with progression of liver diseases like liver fibrosis and carcinoma..then why dont these inhibitors inhibit viral proteases and HCV replication??If they do,then how disease progresses....
According to literature, Cystatins from different sources are currently in use against viral diseases including Hepatitis C. if they actually inhibit viral replication then why their concentration enhanced with disease progression, why they dont stop virus in that case...its only because of virus evolution??