I would like to use mouse model for leukemia treatment. What are your suggestions? Which you prefer to use transgenic models or to induce leukemia in adulthood?
How to induce leukemia in mice?
Please find enclosed papers on murine models for leukemia:
Exp Hematol. 2014 Sep 28. pii: S0301-472X(14)00676-6. doi: 10.1016/j.exphem.2014.09.006. [Epub ahead of print]
Two decades of leukemia oncoprotein epistasis: the Mixed Lineage Leukemia paradigm for epigenetic deregulation in leukemia.
Li BE, Ernst P
J Natl Cancer Inst Monogr. 2008;(39):58-63. doi: 10.1093/jncimonographs/lgn022.
Modeling chromosomal translocations using conditional alleles to recapitulate initiating events in human leukemias.
Lobato MN, Metzler M, Drynan L, Forster A, Pannell R, Rabbitts TH..
PLoS One. 2014 Oct 7;9(10):e109799. Pharmacologic Blockade of JAK1/JAK2 Reduces GvHD and Preserves the Graft-Versus-Leukemia Effect.
Choi J, Cooper ML, Alahmari B, Ritchey J, Collins L, Holt M, DiPersio JF.
Many thanks Ewalds-Kvist for the very informative answer
For example, if I want to calculate Mo equivalent for Ti-1.5Mo-3Sn alloy then what should I do?
29 June 2019 9,214 4 View
if our grade generation capacity is 7000 MW, how much MW from renewable energy such solar can this network absorbs?
09 October 2018 2,999 7 View
I need to know what is the necessary studies and imoprtant requerments which should be avilable in order to get clear idea about how much power from solar energy can be utlized in grid and the...
09 October 2018 3,340 2 View
Can anyone please provide the heat of reaction of Fenton's Reagent? OR full reaction chemistry which can be simulated on Aspen Plus?
10 September 2018 4,297 2 View
Titanium Aluminides are being used in aeroengine applications. Different structures of titanium aluminides can be achieved by heat treating these alloys in binary phase region (Ti3Al+TiAl). Two...
08 December 2017 2,551 4 View
At least how many samples can be taken for quantitative research specially in terms of all statistical test?
28 February 2016 7,565 5 View
Please have a look at the image. I am unable to interpret and reason the peak shift towards left. Moreover the 2nd peak at around 30 is of silver oxide ? the peak is supposed to be of Silver nano...
17 February 2015 933 11 View
16 January 2015 2,704 6 View
I am trying to understand the concept of linear dynamic range in quantitative proteomic. As I am a beginner in Proteomics. How the dynamic range is related with the fluorescent dye for 2DE?
14 October 2014 3,061 1 View
Egypt has the highest prevalence of HCV. What is the major risk factor or history behind it?
17 April 2014 3,086 26 View
Hi, I am trying to construct a multi-layer fibril structure from a single layer in PyMol by translating the layer along the fibril axis. For now, I am able to use the Translate command in PyMol...
02 March 2021 4,569 4 View
Hello! I have a dataset of n=3000 nested within 8 countries with approximately 200 or 400 responses in each country. I originally planned to perform multilevel modelling with 4 dependent variables...
02 March 2021 6,865 1 View
In R-studio, there are many commands of Gumbel package. Arguments are also different. I`m asking about the alpha parameter of the Copula which must be greater than 1. If this is the one used to...
25 February 2021 5,229 3 View
Hello, I asm currently working with alginate and silk fibroin hydrogels. I prepared a blend of alginate and aqueous silk fibroin (straight from dialysis) and resorted to ionic crosslinking to...
23 February 2021 8,249 2 View
I want to map these river geoforms with as little subjectivity as possible. I have a high resolution DEM generated by drone data.
22 February 2021 7,800 3 View
I am currently working on gene clustering based on co-expression pattern in mouse brain. The problem is I do not have some solid way to test my result. Are there any suggestions for databases...
22 February 2021 4,374 3 View
I am planning to work on T2 diabetic animals and check the efficacy of probiotics. My initial plan is to fed B6 animals with HFD for a while. But now, I have the chance to work on ob/ob mice. My...
18 February 2021 6,896 3 View
Hello, I am working on a global scale hydrology GIS project delineating global watersheds and doing some data analysis. I have in the past used hydro1K from the USGS that cover the entire world....
18 February 2021 5,109 5 View
Hello everyone, hope you are well. I am planning to use a Generalized Linear Model in SPSS. I would like to add gender to the model as a covariate, however from what I have read, only continuous...
14 February 2021 8,937 4 View
Hi everyone, I'm having some questions about choosing the right test for my experiment and I hope I can find help here! Here are the settings of the experiment: 1. participants are randomly...
14 February 2021 1,028 4 View