I would like to use mouse model for leukemia treatment. What are your suggestions? Which you prefer to use transgenic models or to induce leukemia in adulthood?
How to induce leukemia in mice?
Please find enclosed papers on murine models for leukemia:
Exp Hematol. 2014 Sep 28. pii: S0301-472X(14)00676-6. doi: 10.1016/j.exphem.2014.09.006. [Epub ahead of print]
Two decades of leukemia oncoprotein epistasis: the Mixed Lineage Leukemia paradigm for epigenetic deregulation in leukemia.
Li BE, Ernst P
J Natl Cancer Inst Monogr. 2008;(39):58-63. doi: 10.1093/jncimonographs/lgn022.
Modeling chromosomal translocations using conditional alleles to recapitulate initiating events in human leukemias.
Lobato MN, Metzler M, Drynan L, Forster A, Pannell R, Rabbitts TH..
PLoS One. 2014 Oct 7;9(10):e109799. Pharmacologic Blockade of JAK1/JAK2 Reduces GvHD and Preserves the Graft-Versus-Leukemia Effect.
Choi J, Cooper ML, Alahmari B, Ritchey J, Collins L, Holt M, DiPersio JF.
Many thanks Ewalds-Kvist for the very informative answer
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