https://www.theguardian.com/world/2020/may/09/children-coronavirus-death-kawasaki
New York warns of children's illness linked to Covid-19 after three deaths
State reports 73 cases of children falling severely ill with toxic shock-like reaction that has symptoms similar to Kawasaki disease
Kawasaki disease is a disease of unknown cause that results in a fever and mainly affects children under 5 years of age. It is a form of vasculitis, where blood vessels become inflamed throughout the body. The fever typically lasts for more than five days and is not affected by usual medications.
Oh; What is wrong with 2020? Are they the plan of decreasing the world population?????
Kawasaki disease was first defined in 1967 by Japan Dr. Tomisaku. Its relationship with Covid-19 is still under discussion.
Kawasaki, ranked second in Turkey that emerged in childhood is the most common acquired heart disease.
Please see the following RG link.
Preprint COVID-19 and Kawasaki Like Disease: The Known-Known, the Unk...
You may follow the link below:
Article Association between a Novel Human Coronavirus and Kawasaki Disease
Dear Dr. Ziarati,
I am sure that streptococci are the trigger of this toxic shock:
STSS, streptococcal toxic shock syndrome.
If You do not use penicillin V to treat Group A Streptococci, the waves of inflammation become higher and higher. That is what we see:
The highest wave of scarlet fever in China and UK since many years (50 in the UK).
Inflammation and coagulation are the main sign of streptococcal infection.
If You do have a high inflammation, You will not find streptococci in the patient.
It is a hyperinflammation, a disseminated intravascular coagulation.
Best wishes
Yours Friedrich
Kawasaki disease is a condition that causes inflammation in the walls of arteries throughout the body. It mostly affects children under the age of 5, though teens can get it too. In addition to fever and rash, kids with the illness may also have bloodshot eyes and swollen hands, feet, mouth, lips, and throat. Kawasaki disease is not contagious, but doctors don’t know what causes it, though they suspect viruses could be one cause. It can damage blood vessels and the heart itself, and even cause a heart attack if not treated promptly, according to the American Heart AssociationThe syndrome, which closely resembles the coronary artery condition Kawasaki disease, is characterized by inflammation, fever, and rash. It can become life threatening when dramatic blood pressure drops and toxic shock occur.https://www.google.com/amp/s/www.nytimes.com/2020/05/13/health/coronavirus-children-kawasaki-pmis.amp.html
In Researchgate we find the answer, written by doctors in Taiwan:
There is a massive overlap between Kawasaki-Syndrome and streptococcal toxic shock syndrome.
occur.https://www.google.com/amp/s/www.nytimes.com/2020/05/13/health/coronavirus-children-kawasaki-pmis.amp.html
Ying-Jut Lin, Ming-Chou Cheng, Mao-Hung Lo, Shao-Ju Chien:
Early Differentiation of Kawasaki Disease Shock Syndrome and Toxic Shock Syndrome in a Pediatric Intensive Care Unit.
Pediatric Infectious Disease Journal July 2015;34:1163-1167
doi: 10.1097/INF.00000000000852
Dr. Lin is member of researchgate.
Dear Barbara Sawicka,
we cannot find streptococci in patients with a hyper-inflammatory-post-streptococcal-reactive disease.
This is also true for rheumatic heart disease, post-streptococcal-reactive-glomerulo-nephritis, psychiatric-and-neurologic-disease-associated-with-streptococci. But all these different diseases, RHD, PSGN, PANDAS are nothing like a unsuppurative reaction to streptococci. Even in erysipelas we do not find streptococci as the relevant cause. But penicillin is still the best drug, not resistance of streptococci worldwide.
Best wishes
Yours Friedrich
Why are so many people dying in Belgium?
Is it possible that the low rate of penicillin-therapy in Belgium over the last years induced a high rate of azithromycin-resistant streptococci? And now the streptococci together with coinfecting COVID-19 appear as hidden killer?
Mission Report: ECDC country visit to Belgium to discuss antimicrobial resistance issues.
20-24 November 2017. Stockholm; ECDC; 2018.
doi: 10.2900/065952
Dear Terry Purvis,
toxic shock and myocarditis = Acute rheumatic heart disease in times of scarlet fever, caused by azithromycin-resistant Group A Streptococci.
The old called it scarlatina maligna sine exanthemate = sudden death.
Best wishes
Yours Friedrich
Kawasaki disease is an illness that causes inflammation (swelling and redness) in blood vessels throughout the body. It happens in three phases, and a lasting fever usually is the first sign. The condition most often affects kids younger than 5 years old. When symptoms are noticed early and treated, kids with Kawasaki disease begin to feel better within a few days. Doctors don't know what causes Kawasaki disease. They believe it doesn't spread from person to person. It's most common among children of Japanese and Korean descent but can affect any child. Kawasaki disease symptoms can look similar to those of other childhood viral and bacterial illnesses. Doctors usually diagnose it by asking about the symptoms (such as a long-lasting fever) and doing an exam.
Dear Nasser Said Gomaa Abelrasheed,
Prof. Alvan R. Feinstein used the Venn-Diagrams to understand the complexity of human disease. In his book 1967 he explained the extremely complicated entitiy of rheumatic fever, rheumatic heart disease and post-streptococcal-glomerulonephritis. (Three overlapping circles = Venn Diagram).
Kawasaki and streptococcal-reactive-diseases are (seen with his eyes) two overlapping syndromes.
My only Kawasaki-patient responded to penicillin-therapy.
He was one of many post-streptococcal-reactive-vasculitis patients in my general medicine praxis. 2002 I could present them to the advisory board of the XV. Lancefield-International-Symposium on Streptococci and Streptococcal Diseases.
The former director of the US-NIAID, Prof. R. Krause, accepted my presentation:
"He is right."
Prof. Fauci is now the director of the US-NIAID. Since 25 years he shows in Harrison's Principles of Internal Medicine a figure for vasculitis.
If there is an antigen, eliminate it.
And Penicillin V does eliminate Group A streptococci.
No resistance.
Nowhere.
Never.
Best wishes
Yours Friedrich
A. R. Feinstein: Clinical Judgement.
The Williams & Wilkins Company, Baltimore, 1967.
Dear Terry Purvis,
76 % do have myocarditis.
Why not call this rheumatic heart disease?
Penicillin is the live-saviour in RHD.
Best wishes
Yours Fridrich
Dear Terry Purvis,
erythromycine, azithromycine and clarithromycin induce resistance in group A streptococci (GAS). The center of disease control (CDC) warned December 2019:
"the percent of invasive GAS infectionas that are resistant to erythromycin has nearly tripled in 8 years". (page 103)
"We have all known someone who has had strept throat - imagine if it were untreatable. Germs would spread, more people would get sick, and some might develop rheumatic fever, a complication of strep throat that can damage the heart." page 104
This is exact the situation we see now:
23 % of the group A streptoccal infections do no react to the popular azithromycin. 3 % of the untreated group A streptocci develop into rheumatic heart disease.
And as general medicine practitioner I had to understand:
Rheumatic heart disease is still with us. (June 2002, Braunschweig. Prof. Richard Krause, former director of the NIAID accepted it. He was one of the first doctors which prevented the rheumatic heart disease in young, healthy soldiers by penicillin injections.)
Only penicillin could prevent this catastrophe.
U.S. Department of Health and Human Services.
Centers for Disease Control and Prevention. Dec 2019:
Antibiotic Resistance Threats in the US 2019.
Dear colleagues,
Dear friends,
the erythromycine-resistance of Group A Streptococci in India is 46 %.
All the killing done worldwide is induced by not giving penicillin in times of scarlet fever.
Best wishes
Yours Friedrich
This is a specific autoimmune disease. Requiring specific suppression of immune responses to an allergen. Treatment is selected (individually). It would be most correct to say that there is still no unified strategy for the management and treatment of such patients. Regards, Sergey Viktorovich Pushkin
Dear Pushkin Sergey Viktorovich,
Allergen: Group A Streptococci.
Immune response: Rheumatic heart disease.
That is no contradiction to Kawasaki-Syndrome.
Best wishes
Yours Friedrich
Dear Pushkin Sergey Viktorovich,
in discussing the issue of Kawasaki-Sydnrome I would like to present a paper from Nigeria:
B. A. Animasahun, A. D. Madise-Wobo, O. Y. Kusimo: Nigerian Children with Acquired Heart Disease:
The Experience in Lagos.
The Journal of Tehran University Heart Center, Oct, 2017, 12(4):160-166.
In 9,5 years the Universitty Teaching Hospital diagnosed from January 2007 to June 2016 in 25,6 % Rheumatic Heart Disease, Dilated Cardiomyopathy in 20,8 %.
Kawasaki in 1,6 %.
I am sure, that this African experience is plain truth also in all other parts of the world.
Only one difference: My generation (borne 1953) thought the old foes vanished.
So Penicillin V vanished and Group A Streptococci became the most efficient killer
in times of COVID-19.
Prof. Rastan, Tehreran, learned heart-surgery in Göttingen, Prof. Koncz.
And we only heard, that he operated many rheumatic heart disease patients in Iran.
Best wishes
Yours Friedrich
the WHO wrote, that there are more than 30 Million people with Rheumatic Heart Disase.
And there is no strict secondary prophylaxis with penicillin.
If we do not give Penicillin V to all children in the world with Group A Streptococci infections, the resistance to modern antibiotics poses 3 % of all 8 billion humans to the risk of developing Rheumatic Heart Disease:
240.000.000 people are at risk.
And penicillin is so cheap, 20 Euro/kg.
Penicillin is too cheap.
Best wishes
Yours Friedrich
"Lack of an acceptable domestic supply of BPG is a significant problem in several global sites where RF/RHD is prevalent. Without consistent access to an inexpensive and high quality supply of BPG, children in areas with a high prevalence of RF/RHD will remain at risk of develping this crippling and life threatening condition."
K. Tauber, S. B. Marko: Access to Essential Mecines: Illuminating Disparities in the Global Supply of Benzathine Penicillin G in the Context of Rheumatic Fever/Rheumatic Heart Disease Prevention.
JACC March 12, 2013, Volume 61, Issue 10. E2004
Dear Prof. Gruenwald,
Oklahoma transferred the streptococci from Germany, Jena, Prof. Koehler to Prof. Ferretti, Oklahoma University. He knows everthing about streptococci and is together with Prof. Koehler editor of the online book: Streptococcus.
Online free.
Prof. Ferretti gave a lecture in Jena 2 years ago.
There is no resistance in streptococci against penicillin.
But only Danmark, Norway, Sweden and Germany still treat with penicillin V.
All other countries try to do it better. And earn resistant group a streptococci, not treatable with their antibiotics.
Best wishes
Yours Friedrich
The post-COVID-19-reactive-diseases are similar to
the post-streptococcal-reactive-diseases.
(From nephritis, carditis to PANDAS).
A double-blind-study with preventive-penicillin-therapy (3 x 1 Mega Penicillin V/d versus Placebo) to prevent inflammatory-reaction post COVID-19 should be easily done.
Best wishes Yours Friedrich
PS:
Circa 70 days after diagnosis 78 % of one hundred post-COVID-19-patients show cardiac involvement in MRT, 60 % still have ongoing myocardial inflammation.
V. O. Puntmann, M. L. Carerj et al.: Outcomes of Cardiovascular Magnetic Resonance Imaging in Patients Recently Recovered From Coronavirus Disease 2019 (COVID-19). JAMA Cardiol. 2020 Jul 27: e 203557
doi:10.1001/jamacardio.2020.3557
Dear Abdelhameed Ibrahim,
Group A Streptococci are in Egypt main trigger of autoimmune-diseases like Rheumatic Heart Disease.
Only widespread penicillin V in cases of sore throat and tropical score will change this.
There is no resistance of Group A Streptococci against Penicillin V.
Best wishes
Yours Friedrich
Dear Abelhameed Ibrahim,
attached a paper about Rheumatic Heart Disease in Egypt.
We need easy access to oral penicillin V as primary prevention of this auto-immune-disease. Penicillin intramuscular, every 2 weeks, is secondary prevention of RHD, to late, not tolerated.
Ahmed Afifi, Hatem Hosny, Magdi Yacoub:
Rheumatic aortic valve disease - when and who to repair?
Ann Cardiothorac Surg 201j9;8(3)383-389
http://dx.doi.org/10.21037/acs.2019.05.01
Dear Parisa Ziarati,
some other papers about Group A Streptococci, Penicillin and RNA/Unfractionated Heparin.
Streptokokken - Bilder einer Krankheit. Grin 2009
www.grin.com/document/123598
Rezept für die Medizin von Morgen. Grin 2011
www.grin.com/document/179988
The fast and the furious phosphor. Grin 2019 (online free)
www.grin.com/document/503046
Best wishes
Yours Friedrich
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