Which sequence could induce higher immunogenicity, S polypeptide or only S1? and how to isolate S1 from a vector containing the whole seq. of S?

02 January 2021 1 8K Report

I have a clone of DNA sequence encoding the full spike protein (S1+S2)

In my opinion, the longer the polypeptide, the more potential b and t cell epitooes, so I would focus on full length spike sequence.

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