I'm interested in the entry mechanism of the Zika Virus into U937 Monocytes.
To the best of my knowledge, the proteins responsible for Zika entry are DC-SIGN, AXL, Tyro3, Mer, TIM and TAM.
Which of the above mediates the docking/entry of the Zika Virus into U937 Monocyte cell line?
Thanks
Avishay
all the receptors that he mentions are involved with the zika virus and the various cells of the nervous system
... Once in the central nervous system, the receptors that mediate the entry of the virus are the transmembrane mannose receptors (RMM) in the astrocytes and the microglia, and the DC-SIGN or CD 209 in the dendritic cells, perivascular cells and cerebral blood vessels. The input to the neural cells is verified, in addition to the DC-SIGN receptors, by the tyrosine kinase receptors: TIM (TIM-1, TIM-4) and TAM (AXL, Tyro-3). The Zika virus induces a negative regulation of TAM receptors, especially AXL, which promotes increased permeability of the blood-brain barrier and loss of endothelial cell binding of the cerebral microvasculature (altered claudii). and occludins), favoring neuroinvasion and viral replication. Once in the neuronal cells, the target of involvement is the endoplasmic reticulum (place where there is a large amount of structural proteins), where viral replication is verified, presenting accumulation of virions that initiate a multiplicative phase; Likewise, the response of unfolded proteins involved in the processes of autophagy is activated, which is increased by viral action of Zika, which mediates the appearance of autophagosomes, to favor viral replication and neurovirulence. In the same way to the induction of fagosomas, the appearance of centrosomes is propitiated, which increase the delay in mitosis and increase in apoptosis. Finally, if the Zika virus infects during the stage of embryogenesis, the neuronal stem cells may be performing multiple asymmetric divisions, which will result in a decrease in the neuronal mass, and in the fetuses, microcephaly and other neurological alterations.
(PDF) EMERGING ARBOVIRUS. Available from: https://www.researchgate.net/publication/329871164_ARBOVIRUS_EMERGENTES [accessed Feb 25 2019].
speaking of monocytes, those expressing CD14 and CD16 are the most likely to attract Zika virus
https://www.nature.com/articles/s41564-017-0035-0
https://www.nature.com/articles/s41564-017-0049-7
Avishay Edri
Plenty of information in this site. May be you find here something
http://memorias.ioc.fiocruz.br/fast-track
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