Depending on the number of replicates you have, you can use several packages. The most famous and used are edgeR and DESeq2, but if you are working without replicates, then you can try NOISeq, that helps to simulate replicates, to infer differential analysis on your samples.
Both edgeR and DESeq2 are really very good tools for DEG analysis and widely used. Depending on your data you can use anyone. DESeq2 gives more stringent and generally used for replicate data and for without replicating data it shows some warning message while running like "samples treated as replicate for estimation of dispersion". For detailed information, you can visit the website mentioned below.