I want to make excision wound model in rats for the study of drugs for healing potential. So, i want to know that is simple open excision wound model is better than stented wound model in rats or vice versa?
Pylorus Ligation-induced Gastric Ulcer Model may be simple and utilized for your study.
Dear Sir,
I don't know about your study of drug for healing potential but I suggest this paper from Thakur R. et al. , study for wound healing.
For initial assessment of the potential of your drugs first in vivo wound healing model must be mice model of incisional wounds. This model minimizes artifacts and reveals full potential of your drugs on different wound healing stages and processes. The study should be conducted on healthy mice in order to examine in parallel both efficacy and safety of the drug candidates. From my personal experience (which is development of several dermal/wound healing drug candidates from basic research to advanced stages of clinical development) I recommend to pick up only those leads that are able to improve wound healing in healthy mice.
Article that describes the model is – “Novel insights into wound healing sequence of events.”
Abstract - http://www.ncbi.nlm.nih.gov/pubmed/17943650
Full text - http://tpx.sagepub.com/content/35/6/767.long
I may address any questions you have regarding the article and the model. Moreover, since that article we improved the assessment protocol and increased clinical relevance of the model. This work still not published, but I may share with you some details if needed. Good luck!
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