Which kind of immunization with irradiated cancer cells (strength and/or incidence ) can trigger a tolerogenic DC response?

03 July 2014 1 8K Report

I want to generate an anti tumor response for cancer treatment with irradiated B16F10 melanoma cells, therefore I want to avoid a tolerogenic response when injecting mice with these cells.

Ishak Ozel Tekin

You can use IL-10 or TGFbeta with crude antigens. Actually, B16F10 alone can trigger a little bit tolerogenic responce.

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