The first is originated from rat and the later from human origin. Both are secondary cell lines and could be differentiated into neuronal-like cells.
#Alzheimer's and Parkinson's disease
#neuronal cell model
#neuroprotective effects
Perhaps you could state what you intend to study in neuronal cell model ?
PC12 cells are excellent for studies on exocytosis and neurite outgrowth. See the article on SHSY5Y cells,
"Considerations for the use of SH-SY5Y neuroblastoma cells in neurobiology" Kovalevich and Langford PMID 23975817.
If you are interested in a specific neurodegenerative disease, you may be better off trying to obtain IPS cells harboring that disease. Primary cultures of neuronal cells are not difficult, however they require live rodents but allow you take advantage of many readily available transgenic and knockout models.
reach me at [email protected] with your full name , institute name and country with a full query and i will guide you though these issues for solution
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