Tn I and T only found in heart muscle, but Tn I is more specific cardiac enzyme than Tn T. Clinically, it depend on the available kit in hospital, but both enzyme are gold standard for diagnostic Acute MI.
I am not aware of a study showing an advantage of TnT over TnI or vice versa, especially if you use the high sensitive assays. TnT is offered by Roche whereas TnI is offered by several companies and in a normal setting you will find no lab offering both assays, its too expensive to hold both assays available.
It is troponin I that is recommended for assessing cardiac injury. Please mind that despite its high specificity, there are a number of non-cardiac conditions where is raised. But contrary to chronic conditions, dynamic changes in levels are indicative of acute events.
It would be helpful to specify what does dear Dr. Eshah mean "more indicative" (specific, sensitive or general applicable in clinical settings) and which AMI - STEMI, NonSTEMI, etc.?
Concerning comparison of high-sensitivity-cardiac troponin I vs. T for the early diagnosis Non-ST-AMI see the reference, please: http://eurheartj.oxfordjournals.org/content/ehj/35/34/2303.full.pdf
As conclusion:
"Both hs-cTnI and hs-cTnT provided high diagnostic and prognostic accuracy. The direct comparison revealed small but potentially important differences that might help to further improve the clinical use of hs-cTn".
Dr. Taradin said it all (and thanks for the article)!!! Question closed!
In our experience the TnI shows more consistency for this type of diagnosis. TnT changes more easily, giving us more false diagnoses than TnI.
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