The concept of management of epilepsy in human is not so much hinged on 1st line, second line drug choices. What is crucial is to consider the following:
1. Classification of Seizure Type/Epilepsy syndrome
2. Gender/Child bearing age
3. Elderly patients
4. Co-morbidity (Hypertension, DM, HIV) hence look for drug-drug interaction, which AEDs are predominantly metabolised through the kidney or liver, enzyme inducers etc.