As has been suggested and proven, among multiple triggers of autoimmunity, some infectious diseases agents, would do that. My question, which are the most likely viruses that can induce autoimmunity?
Autoimmune reactions often result from infection with a virus. The HLA system cuts pieces (8-10 a.a. for Class I to CD8+, longer for Class II to CD4+ T cells), of viral peptides. This helps in recognition and destruction of infected cells, but if the HLA type captures the same fragment of a normal protein like MBP, this results in auto-immunity. So, the only requirement is for a systemic infection, but viruses which target long-lived structural cells will often trigger more auto-immune reactions than those infecting epithelial or blood cells. So, its more of an HLA and self-T cell repertoire.
Herpesviridae (Cytomegalovirus, herpes simplex viruses (HSV)-1 and -2, varicella-zoster virus (VZV), and Epstein–Barr virus) are related with the onset of different automimmune diseases
Coxsackievirus are linked to type 1 diabete mellitus (CVB4) , some of them are associated with autoimmune myocarditis ( CVB3)
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