I am working with C.elegans strain which expresses H.s. GRP94 protein.
I am looking for proper antibody to detect GRP94. Do you have some recommendation or suggestions?
Hello Agnieszka,
anti-Grp94 antibodies were used to detect Grp94 in investigations described in
1) Tramentozzi E, Ruli E, Angriman I, Bardini R, Campora M, Guzzardo V, Zamarchi R, Rossi E, Rugge M, Finotti P. Grp94 in complexes with IgG is a soluble diagnostic marker of gastrointestinal tumors and displays immune-stimulating activity on peripheral blood immune cells. Oncotarget. 2016 Sep 20. doi: 10.18632/oncotarget.12141. [Epub ahead of print] - (rabbit polyclonal, Enzo Life Sciences);
2) Shen J,Yao L,Lin YG,DeMayo FJ,Lydon JP,Dubeau L,Lee AS. Glucose-regulated protein 94 deficiency induces squamous cell metaplasia and suppresses PTEN-null driven endometrial epithelial tumor development. Oncotarget.2016 Mar 22;7(12):14885-97;
3) Ostrovsky O, Makarewich CA, Snapp EL, Argon Y.An essential role for ATP binding and hydrolysis in the chaperone activity of GRP94 in cells. Proc Natl Acad Sci U S A. 2009 Jul 14;106(28) - (anti-GRP94 monoclonal antibody 9G10);
4) http://www.cell.com/cms/attachment/2038221091/2052462163/mmc1.pdf - (monoclonal anti-GRP94, 9G10 );
5) Mao C,Wang M,Luo B,Wey S,Dong D,Wesselschmidt R,Rawlings S,Lee AS. Targeted mutation of the mouse Grp94 gene disrupts development and perturbs endoplasmic reticulum stress signaling. PLoS One.2010 May 26;5(5):e10852 - (rat anti-GRP94 antibody).
I hope it helps you. With best wishes, Elena
- Badges
- Science topic
- Similar topics
- Biological Science
- Immunology
- Antibodies