Could anyone tell me where I can order HA15 (modified TZD) used in the following research to treat melanoma cell?
http://www.cell.com/cancer-cell/abstract/S1535-6108(16)30171-4
Dear Chengdong Wang,
this your question is not only interesting but hardly can be answered seriously since authors of that article don't mention a / the source of HA15 (I guess they have synthesized by themselves and only have shown a sketch of the chemical formula - if that is not only fictional one - cf. the 'graphical abstract ').
On p.-2- (section: RESULTS
HA15 Exerts a Deleterious Effect on Melanoma Cell Viability find the word:
'tro-glitazone' ) and in their Fig.1A on page -3- you will find a hint what HA15 is:
(A) Chemical structure of troglitazone and HA15.
I am sure that the results - though really promising (I have seen that TZD compounds also have been found useful in treating Diabetes(II)) - are derived from the preclinical testing phase and therefore also pending patents will have be taken into account.
From the two links you provided with your question I deduce you had NO access to the whole article, right? IF so, I would like to add here the URL where you can find (at least an online version) the whole article including supplementary pages/data:
Cerezo et al., 2016, Cancer Cell 29, 1–15 June 13, 2016 ª 2016 Elsevier Inc. http://dx.doi.org/10.1016/j.ccell.2016.04.013
http://www.cell.com/cms/attachment/2057191903/2061581406/mmc2.pdf
(via that latter URL at least for me the article was open access online)
I guess that it might be possible to get into contact with the corresponding authors of that article.....and perhaps these will reply (at least if they are collegial and ).
'Correspondence:
[email protected] (R.B.= Rachid Benhida, Institut de Chimie de Nice UMR UNS-CNRS 7272, Université Nice Sophia Antipolis, Parc Valrose, 06108 Nice cedex 2, France ),
[email protected] (S.R.= Stéphane Rocchi : INSERM, U1065, Equipe Biologie et Pathologie des cellules mélanocytaire: de la pigmentation cutanée au mélanome, Centre Méditerranéen de Médecine Moléculaire (C3M), Bâtiment ARCHIMED, 151 route de Saint Antoine de Ginestière, 06204 Nice cedex 3, France; AND: UFR de Médecine, Université de Nice Sophia Antipolis, 06000 Nice, France; AND: Service de Dermatologie, Hôpital Archet II, CHU, 06204 Nice, France.
Hope, that can be of help, my best wishes and good luck, WM.
Dear Wolfgang, thanks for your detailed answer and whole article link. It helps a lot.
- Badges
- Science topic
- Similar topics
- Biological Science
- Cell Biology