i used the deep eutectic solvent as reaction solvent, but it really thick. so i want add other solvent to reduce the thick problem, like dichloromethane. The react is esterification reaction, i don't konw that adding dichloromethane has any effect for the deep eutectic solvent and the reaction.
First, I would see if DCM is miscible with the deep-eutetic solvent but if you are using a strong base (BuLi or LDA) could be problems
Maybe DMF or DMA could be better since those are more polar than DCM
Viscosity is an intrinsical property of the DES, so maybe consider the idea of replacing your DES with another one having power viscosity. Personally, I would not add any solvent: if you used something nonpolar (e.g. DCM) you would obtain a biphasic mixture, while if you added something polar (e.g. water, DMF, DMSO), you would destroy the hydrogen bond network, so to disrupt the unique structure of the eutectic mixture (assuming that you are using a real Deep EUTECTIC solvent)
Marcos Martínez Fernández This worth a try. I'm a newcomer to organic synthesis, i have recently been trying to duplicate the synthesis of a paper, but we don‘t get the same product. This leads me to believe that my operation is not up to standard, so I will use some common methods to react. Thank you very much for your answer, it's my first time to use the ResearchGate.
Achille Antenucci Thanks for your answer. At first, i support that the viscosity of DES will increased with the other solvent added. but when i read some books, i realised it is a mistake method that it would destroy the hydrogen bond network, like you said. So, i will use other solvent instead the DES. Too difficult for a newcomer to organic synthesis. （crying.....）
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