Mohammad Alkhatib ,

I agree with most of your answer to the discussion question; however, the Pfizer vaccine was tested on thousands of volunteers way back in January 2020, and Pfizer's scientific research resulted in an estimated efficaciousness rate well above the norm of 60%, which is to say that Pfizer claims 90% or higher for the efficaciousness of their vaccine. In addition, a chart plotted the development of the novel COVID-19 viral infection in those volunteers who only received the placebo as gradually rising at a rate consistent with the infection rate observed in the general population, which grew in numbers steadily from January 2020 up to the present. In striking contrast, those individuals who were vaccinated with the Pfizer vaccine show a flat profile that runs parallel to the zero line at the bottom of the chart. The approximate 60 degree angle differential between the two populations who were given the Pfizer vaccine, on one hand, and a placebo, on the other hand, strongly suggests that the Pfizer vaccine is strong enough to prevent the novel COVID-19 virus from infecting those who are vaccinated. Evidently, none of the volunteers who participated in this controlled laboratory research was found to be allergic to any of the ingredients used by Pfizer.

In this regard, I do not know if Pfizer used any ingredient like melatonin, but a national television news broadcast today reported that some ethnic groups seem to benefit, that is, those African Americans who customarily took melatonin as a supplement in tablet form as a sleep aide because it is milder than sleeping pills appear to reduce the incidence of being infected by the novel COVID-19 virus by about 30%. There is also a possibility that an individual's good health, attained by eating nutritious foods, getting enough rest and sleep, and nonstrenuous exercise, contributed to the beneficial effect of melatonin generally, and more specifically in helping to prevent being infected by the novel COVID-19 virus.

We are in Lithuania as probably most of EU countries are going to receive Pfizer vaccine. Also, there is an agreement with Astrazenece

i fear the unseen /known/ untold sides effects of the vaccine !

I fear from un expected consequences of the vaccine

I just wanr to be safe from covid-19 and plan to take the vaccine onxe it is available. However, we jzat did a reseaech on students and xovid-19, and laege majoeity od them do not want to take it.

The serious adverse reactions, the failure to protect from COVID-19 infection and long term effects of the vaccine.

I believe the most in Chinese vaccine sinopharm because it has been tested on hundred of thousand of people with more than 85% effectiveness in producing antibodies and preventing the virus infection. While Pfizer and Moderna vaccines showed more than 90% efficacy in generating antibodies but have not been tested in a large population and have not even shown to prevent or resist to the virus

Too little information about Moderna vaccine. Initial indicators show that it may be the best vaccine from COVID-19 (keeping, effectiveness, etc.) - why is this not reported? Or, may be, I am wrong, as I am not a specialist in this field.

I am in fear to receive it because it will not be available for developing countries.

Agreed with Dr. Muhammad Ihsan

Dr. Israel Junior Borges do Nascimento,

The vaccine for COVID is still not manufactured. So, It is quite challenging for everyone to say anything about the harmful and useful effects of the vaccine. However, there are a lot of medicines in the race to win the crown. We can try to contribute something in this unexplored area of this translational research.

Provided the COVID-19 vaccine is available in all countries, the two most common factors for not getting vaccinated will be:

1. Cost: In many countries, where due to economic constraints the Government will not provide it free, cost could be prohibitive (average cost for 2 injections of vaccine will be $ 70 (35x2). In such situations the cost will be the major reason why people will not get vaccinated.

2. Neurological side-effects: There have been reports of Transverse myelitis, and Guillain-Barré syndrome (1-2).

1. https://www.statnews.com/2020/09/09/astrazeneca-covid19-vaccine-trial-hold-patient-report/

2. https://www.quora.com/q/coronavirus?__ni__=0&__nsrc__=4&__snid3__=15001826883&__tiids__=17138786

How many people will accept to get a COVID-19 vaccine?

The acceptance rate for a COVID-19 vaccine when provided free has been projected to be 60-70% in different countries (1-3). However, it will also be dependent on the proven efficacy of the vaccine being used in a particular population (4).

1. Article Determinants of COVID-19 Vaccine Acceptance in Saudi Arabia:...

2. https://www.pewresearch.org/science/2020/12/03/intent-to-get-a-covid-19-vaccine-rises-to-60-as-confidence-in-research-and-development-process-increases/

3. Article A global survey of potential acceptance of a COVID-19 vaccine

4. Article Acceptance of a COVID-19 Vaccine in Southeast Asia: A Cross-...

Personally as a health care personal working directly with potential or actual COVID-19 patients, I would get the COVID-19 vaccine as and when mandated by my hospital.

As Pulmonologist dealung with many confirmed or suspected COVID-19 cases, i wish to be able to receive the vaccine, but on the other hand i keep thinking is 7 months are enough to gauge safety of any medication?

fear of unknown

Hoping for it but it seems to be not for developing countries.

People are fearing efficacy- I believe even 50% will be enough.

Safety has been proven till now; long -term safety will eventually unfold.

I will definitely get the vaccine and encourage all

Yes, currently it is the only option to fight at a personal front apart from social distancing and infection prevention strategies.

in the UK, Pfizer has been sanctioned with its cold chain supply issues. AstraZeneca Oxford vaccine is being evaluated by the MHRA- it’s approval will be useful since cold chain supply not an issue.

Mohammad Alkhatib ,

I agree with most of your answer to the discussion question; however, the Pfizer vaccine was tested on thousands of volunteers way back in January 2020, and Pfizer's scientific research resulted in an estimated efficaciousness rate well above the norm of 60%, which is to say that Pfizer claims 90% or higher for the efficaciousness of their vaccine. In addition, a chart plotted the development of the novel COVID-19 viral infection in those volunteers who only received the placebo as gradually rising at a rate consistent with the infection rate observed in the general population, which grew in numbers steadily from January 2020 up to the present. In striking contrast, those individuals who were vaccinated with the Pfizer vaccine show a flat profile that runs parallel to the zero line at the bottom of the chart. The approximate 60 degree angle differential between the two populations who were given the Pfizer vaccine, on one hand, and a placebo, on the other hand, strongly suggests that the Pfizer vaccine is strong enough to prevent the novel COVID-19 virus from infecting those who are vaccinated. Evidently, none of the volunteers who participated in this controlled laboratory research was found to be allergic to any of the ingredients used by Pfizer.

In this regard, I do not know if Pfizer used any ingredient like melatonin, but a national television news broadcast today reported that some ethnic groups seem to benefit, that is, those African Americans who customarily took melatonin as a supplement in tablet form as a sleep aide because it is milder than sleeping pills appear to reduce the incidence of being infected by the novel COVID-19 virus by about 30%. There is also a possibility that an individual's good health, attained by eating nutritious foods, getting enough rest and sleep, and nonstrenuous exercise, contributed to the beneficial effect of melatonin generally, and more specifically in helping to prevent being infected by the novel COVID-19 virus.

I do not think so!

Nancy Ann Watanabe

I appreciate you very informative comment.

I personally believe that when more people get the vaccine, more secure it will be, regardless vaccine name and origin.

Best Regards

Hermann Gruenwald Your comments lack any scientifcíc basis.