Tumor heterogeneity is widely accepted at the population level within the tumor. Minor population within the tumor cells known as CSCs are thought to be highly drug resistant compare to non-CSCs. I want to know about your opinion on expression of death receptors on CSCs and non-CSCs. Is there any study about the study of or expression of DR4 and DR5 within the same cell line or patient sample?
DRs are receptors for TRAIL, and mediate TRAIL-induced apoptosis in cancer cells. Signaling through DR may influence apoptosis. Apoptotic efficiency of TRAIL upregulates through upregulation of DRs in tumor cells. DR expression on endothelial cells within tumors has been reported, which might be linked to antitumor activity. DR expression on endothelial cells would lead to the disruption of tumor vasculature and reduce tumor growth.
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