It was observed that the allergic patients have 1350 % elevated level of IgE in systemic circulation as compared to healthy individuals. What would be the numerous symptoms observe during this situation. How to control allergies like urticaria/itching under such condition. Which one is the best class of drug to control it i.e. Immune suppressant like Azathioprine or Antihistaminics or Others class of drugs?
There is a monoclonal antibody against IgE, olimazumab. It is used in some conditions to lowering the IgE level. However is quite expensive, and is only used when there is no other way to control symptoms.
I do not fully understand your question, as in "allergic patients" the symptoms might be obvious. I am also struggling with the plural in patients.
Because of the extremely high IgE level, the following article might be of furthr help:
Hagl et al 2016, Pediatr Allergy Immunol.
PMID:26592211
Elevated IgE causes no symptoms. Elevated IgE is a result of a process such as an allergic response to multiple allergens or a mutation such as STAT3. The high IgE's seen in eczema or Hyper IgE Syndrome are an epiphenomen, not the cause of symptoms.
"Elevated IgG" has no symptoms since it is not a disease but a part of pathophisiology.
it mostly related to hyper IgE syndrome (HIES). Azathioprine or Antihistaminics work with possible outcome
need further information read this article Elevated serum immunoglobulin E (IgE): when to suspect hyper-IgE syndrome-A 10-year pediatric tertiary care center experience.
PMID: 19331717
I agree with Dr.Wassermann and Dr.Olivier , There is no symptoms for elevated IgE, because it is not a diseases .
Dear colleagues! In addition to what has already been said by others, I want to say. IgE specifically interact with basophils and mast cells, containing granules with numerous biological active substances (histamine, etc.).
The release of these substances during the degranulation causes the development of an allergic reaction to the formation, depending on the body of the shock, the symptoms of asthma or allergic rhinitis or urticaria. Furthermore, protective properties of IgE also directed against helminths. IgE synthesis increases in parasitic diseases, mycoses, IgE - monoclonal myeloma, as well as in primary immunodeficiency. Allergist tactics in search causal factor overproduction of IgE should be based on a properly assembled Allergic history.
Sincerely, Alima Akhunova.
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