Based on some observations i found that an imepenem resistant Pseudomonas aeruginosa had different colony morphology from its wild type. So, does this phenomenon occur in other bacteria? If yes what could be a possible explanation?
Colony morphology - particularly the colony size could vary depending on the nutritional factors and pressure of having been exposed to antibiotics invivo.
Its worth looking into the typing methods to see if there is any minor difference in the genotype.
A change in colony morphology could be readily explained by the fact that the particular antibiotic (imepenem) affects cell wall synthesis, and therefore resistance to it would likely allow the organism to grow, but perhaps not without some effect on the cell wall and therefore, colony morphology.
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