What will happen if my drug doesn't follow lipiniski rules

More Rimon Parves's questions See All

Can MaxQuant be set up to detect sodium ionisation of peptides?

Due to factors outside of my control, peptides in my ESI-MS data have been ionised normally by protons ([M+2H], [M+3H]...) but also by sodium ([M+2Na], [M+3Na]...). Is there a way to configure...

16 April 2024 10,028 2 View

How to prepare 4L saturated sodium borate solution for Neutralization in cartilage staining?

I have crystal sodium borate. I need to prepare saturated sodium borate solution. I don’t understand the measurements Between water and sodium borate.

17 June 2023 7,020 0 View

Has anyone managed to resolve very low protein recovery from Zeba desalting columns?

We work with a range of nanobodies (13–17 kDa), and while some go through desalting procedures without much trouble, others essentially disappear on the Zeba™ resin, with recovery rates as low as...

07 November 2022 5,307 0 View

Can I get research topics in medical physics?

Or anything related with shielding materials and dosimetry for medical application. I need topics that can be researched on and suitable for undergraduate research work. Thank you.

25 July 2021 9,533 10 View

Problem with employing GPU with NAMD ??????????

Hello, I have updated NAMD to the recent one NAMD v2.14 release (CUDA version). After installing the software well, I ran a system and found poor performance. With my following PC configurations...

07 October 2020 1,509 2 View

Can I use a C18 SPE cartridge with a simple syringe plunger?

C18 SPE cartridges can be useful for purification of small hydrophobic molecules from a solution that also contains proteins, buffers and salts. As far as I can tell, they can also be used for the...

27 February 2020 4,882 5 View

What is the toxicity mechanism of propargylamine?

Propargylamine (AKA 2-Propynylamine, 3-Amino-1-propyne) is a liquid which carries the hazard statement H310: "Fatal in contact with skin". With a dermal LD50 of 66 mg/kg in rats, the hazard...

12 March 2019 1,099 1 View

Is there any research on Neighborhood Environment Walkability in the cities of Bangladesh?

We have recently started a project on neighborhood environment. The interests are to explore existing precarious conditions and suggest possible solutions. Can anybody help me to theorize the...

21 September 2017 8,269 3 View

Could anyone suggest what honeypot i can use to analyze malware with mem maps preferably in linux?

i am looking for suggestion to what type of honeypot i can use? probably suggestions? any new area i can work on? any related research paper? please suggest.

21 September 2016 7,496 2 View

Is there any research in relation to Lightning Death?

Recently, Bangladesh is experiencing huge lighting death. I am very much interested to pursue a research to document geographies of lightning death in Bangladesh as well as in the world. I need...

16 May 2016 2,184 3 View

Is changing the medium during the experiment overestimate the results?

I am experimenting with cancer and non-cancer cells in a 12-well plate for 4 days with a seeding density 1*10^4/well, however, I noticed that the control group growth rate slows down on D3. Should...

07 August 2024 2,283 2 View

Why don't d-orbitals split themselves, why does it take a ligand? why don't protons from ligand repel nucleus split d-orbitals?

why don't d-orbitals split themselves because of themselves without the presence of ligands? Electrons are indistinguishable. Why wouldn't it be more correct that protons from a ligand split the...

03 August 2024 3,589 3 View

Why doesn't chromium 2+ ion use all its d-orbitals to receive lone pairs from six waters in [Cr(H20)6)]3+?

I'm guessing it's because the ligand experiences too much electron repulsion or proton repulsion from the chromium to insert them close to the 3d-orbitals which are close to the metal nucleus. Is...

03 August 2024 1,370 1 View

Which solvent is better to dissolve with secondary metabolites extracted from fungi?

I work on MCF7 cell cell for anticaner purpose and I wa to do drug preperation the drug ( secondary metabolites extracted from Aspergillus) My question which solvent is better with these secodary...

03 August 2024 4,725 2 View

Can i quantify a nanoparticle encapsulated in cell culture medium by hplc?

Hello, if you made a transwell assay where you incubate the cells with a nanoparticle-encapsulated drug and considering that in the oposite compartment you'll have both the free and encapsulte...

03 August 2024 2,730 1 View

How can you draw a coordinate bond between a metal and donor atom in metal complexes, using discovery studio visulizer software?

Hello,, The metal complex ligand appears incomplete in the screen of the discovery studio visualizer

30 July 2024 3,354 1 View

AutoGrid and Autodock 4.2.6 window opens for 1 second then closes and there is no output files?

Good day, I am a student trying to work on Autodock for a project regarding Ligand-DNA interaction so i am quite new to molecular docking. i have followed tutorials and did all the steps...

28 July 2024 2,136 4 View

How to maintain the drug concentration in cell culture study for long term?

I am working in the filed of long acting drugs with Nano formulation. I want to study the efficacy of my formulation in 2D cell cultures while this required media change on every two days. In such...

24 July 2024 8,696 0 View

How can I determine if a drug binds to a ribosome using a Cryo-EM map?

Hello, I am searching for the binding position of a drug in a ribosome, based on previous work indicating it binds there. The resolution of the ribosome-drug Cryo-EM map is around 2.5 Å. I've been...

19 July 2024 2,155 0 View

How to determine LOD values?

I am performing fluorescence experiments using a ligand to detect metal ions. I want to determine the Lowest Detection Limit (LOD) using the formula LOD = 3σ / K. However, I'm uncertain about...

19 July 2024 1,086 1 View