I think one can try scientific positions in different funding agencies as project evaluator, proposing new schemes and evaluating current scientific needs and solutions...
1. What is the country of residence ? Developed world usually have many options and facilitate the persons with disability. In the low resourced countries a person on wheelchair and restricted mobility might not have many options.
2. Educational level : many professional field require manual work and extensive moving. This might not be feasible for a person on wheelchair. But certain professions do not require too much mobility and can be performed on desk or in front of a computer screen
3. Motivation and Medical Condition: Depending upon the medical diagnosis, the person might not be able to do a job that demands prolonged sitting
Having said this all, there are exceptional people on wheelchair with major disability who have followed their dreams successfully and did wonders. e.g. Athletes in para-Olympics, Stephen Hawking, Christopher Reeve ( Superman) and others
I think it depends on person's level of education, job interest along with contextual factors. However, people can choose alternative jobs or professions considering their own limitation. Furthermore, the persons with disabilities should focused on their unaffected limbs through which they can provide their maximum effort.
I would like to add an example, if someone would be a computer engineer before, spinal cord lesion, he or she can continue his or her previous job if they would get an accessible environment. On the other hand, if there is not any possibility to continue previous job, then he or she can be self employed such as can act as a computer trainer or other online computer science related activities.