there are some studies on this, e.g. reference mentioned below 

Am J Perinatol. 2001 May;18(3):169-74.

A prospective controlled trial of albuterol aerosol delivered via metered dose inhaler-spacer device (MDI) versus jet nebulizer in ventilated preterm neonates.

Khalaf MN1, Hurley JF, Bhandari V.

Author information

Abstract

The objective of this study was to identify the most efficient and cost-effective nebulizer device for delivery of albuterol aerosol as a bronchodilator in ventilated preterm infants. Bronchodilators are frequently used as part of the therapeutic regimen of ventilatedpreterm infants. This can be delivered by different types of nebulizers like the Jet or metered dose inhaler (MDI) spacer device. Fifty-three premature infants being ventilated for RDS (24 to 34 weeks of gestation) were studied just prior to extubation. Twenty-four of them received standard doses of albuterol aerosol via Jet nebulizer and 29 via MDI-spacer. Heart rate, respiratory rate, oxygen saturation, lung compliance, and airway resistance were monitored prior and 15 minutes after albuterol delivery. There were significant changes in the parameters studied between pre- and postnebulizer treatment. In both groups, there was a significant improvement in lung function as evidenced by 13-24% decreased airway resistance (RAWE) and 3-7% increased lung compliance (CDYN). There was also a beneficial clinical response as demonstrated by increased oxygen saturations. These findings suggest that both MDI-spacer and Jet nebulizer are equally effective in delivering the albuterol aerosol to the lower respiratory tract. Since a small dose of albuterol delivered via the MDI-spacer improved lung function as effectively as a higher dose via the Jet nebulizer, the MDI-spacer would be the preferred mode of aerosol administration, especially because it takes only 2 minutes to deliver it. Furthermore, it was also cost-effective as one MDI-spacer treatment costs 2 cents, while a Jet treatment costs 10 cents in our neonatal intensive care unit (NICU).

Dear Michael, This article will help you

Lancet. 2016 Apr 30;387(10030):1867-78. doi: 10.1016/S0140-6736(16)30245-8. Epub 2016 Apr 28.

High-flow oxygen therapy and other inhaled therapies in intensive care units.

Levy SD1, Alladina JW1, Hibbert KA1, Harris RS1, Bajwa EK1, Hess DR2.

MDI

A proper use of MDI will we better why are less time consuming and evited fluids on patient airway

As a registered respiratory therapist, I have seen first hand the results of using an MDI with a mechanically ventilated patient. We (RT's) appreciate when MD's order the MDI because it is a much quicker option and works just as effectively as a nebulizer treatment. When working in the ICU, sometimes time is a major constraint and the 2 minutes it takes to give an MDI vs 10-15 minutes with the nebulizer makes a world of difference.

MDI  use manually is more effective for patients on ventilator. Main problem of line nebulizer is a plenty of depot in ventilator line.

We think will be better use MDI because it use eviting respiration tube condensation of water on respiratory circuits

MDI using aerochambers in ventilator circuit should be used over nebulisers

I think it will still differ from patient to patient

Cochrane Database Syst Rev. 2013 Jun 6;(6):CD008863. doi: 10.1002/14651858.CD008863.pub2.

Metered dose inhalers versus nebulizers for aerosol bronchodilator delivery for adult patients receiving mechanical ventilation in critical care units.

Holland A1, Smith F, Penny K, McCrossan G, Veitch L, Nicholson C.