I am starting a project to treat cancer by controlling T regulatory cells or by CD4 T cells anti-tumor response. I need to know what tumor type and mouse model I should use ? thank you
There is no specific tumer that could eleminated by CD4 Tcells or T reg. On other hand what u need to do is pick up type of tumor that cab isolated without the need for mouse killing ie.. biopsy .. try to i solate T cells then incubate them along with tumor cell ..soon after try to measured cytokines profile and compare with basic estimation then identify specific response .. try to increase expression of that profile ..reinject into the mouse ..follow up by histopathologh ..