Compartment pressure syndrome presents as either acute or chronic.

Acute is most often the result of high energy trauma and is a medical emergency requiring fasciotomy. If not treated promptly it can lead to tissue death, deformity, amputation and in rare cases death.

Chronic or Exertional compartment syndrome is most often induced during exercise and resolves when exercise is discontinued. Treatment may be non-emergency fasciotomy.

Intra-compartmental pressure syndrome is diagnosed by clinical signs and symptoms augmented by measuring intra-compartmental pressure invasively.

It is desirable to identify means to measure intra-compartmental pressure non-invasively or to identify and develop alternative means to non-invasively assess Compartment Pressure Syndrome via another surrogate for pressure or for cell/tissue status.