I have found a number of K/R sites which are methylated, I want to next assess whether methylation is required for function. I know in phosphorylation studies we mutate Ser->Ala, Thr -> and Tyr -> Phe. The mutated residues lack a OH group thereby preventing phosphorylation, furthermore they are quite similar in structure so I understand that.

With methylation studies what should I mutate the residues to? I have read Arg goes to Ala/lys and Lys goes to Arg is this right and why?