Dear Reserachers
i want to ask you about plant which have antibacterial. As you know, plants is going to take important point fighting against higly resistance bacteria, fungus etc. Also inhibits resistance patterns. My question is which proporties a plant must include. Can we say chemical compounds like alkoloids, flavonuids make plant strong antibacterial effect?
Best wishes
This question is hard to answer as is. Plants contain thousands of compounds, many of which can have antibacterial activity in-vitro. It also depends very much on what kind of bacteria you want to inhibit. Many relatively simple compounds do inhibit bacteria in-vitro, or can be used against external bacteria. Many more complicated compounds (e.g. tannins) are antibacterial or antiviral externally, but can't be used IV.
The best strategy would be to first think about what kind of bacteria you need to inhibit. Then search the literature for plants that were successfully employed to inhibit these bacteria, and then search for other plant candidates that might have related compounds.
Overall Alkaloids, Lactones, Flavonoids, Polyphenols, Essential oils, Terpenoids, Anthraquinones are the most commonly found compounds with antibacterial activity, but, again, very much depending on what bacteria you are looking at.
Dear Ibrahim,
The spices cloves, nutmeg, cinnamon, bay leaves contain eugenol, a clear to pale yellow oily liquid with a pleasant, spicy, clove-like odor, that can be extracted from the essential oils from these plants. Eugenol is used in perfumeries, flavorings, essential oils and in medicine as a local antiseptic and anaesthetic. Combining zinc oxide and eugenol forms zinc oxide eugenol which can be used as a filling or cement material used in dentistry. It is classified as an intermediate restorative material and has anaesthetic and antibacterial properties. It is sometimes used in the management of dental caries as a "temporary filling".
From this paragraph it can be concluded that all plants contain Eugenol have the potential to be used for microbial infections treatment.
Hoping this will be helpful,
Rafik
The phytochemicals within the plant may have the antibacterial activity. I agree that the presence of major groups of phytochemicals such as flavonoids, terpenoids, alkaloids, phenolics do contribute towards the pharmacological activity of the plant. I would like to add the existence of synergy between the phytochemicals to significantly enhance the biological activity.
@rainer
Thanks for answer. i am new at this area and very attractive for me because i try to fight resistence nozocomial pathogens like klebsiella and pseudomonas. i know its very difficult to know "this bacteria have antibacterial effect". need some literature research. your advises will help me for my goal. thanks again.
@rafik
its very clear for me. Thanks
@ibrahim
i think so.
@bhavesh
next i will try synergy with essential oils and antibiotics.
Dear Ibrahim,
Plants contain various phytoconstutents that are very complex in nature. In-vitro studies suggests us phytoconstitutents including alkaloids, flavonoids, tannins, essential oils, saponins, terpenoids are capable of showing antimicrobial activity. Sometimes these phytoconstituents revel synergistic the effect which might be potential for antimicrobial activity.
Best of luck
Some have mentioned polyphenols but no-one said phenols. Phenols are strongly antimicrobial.
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