I prepared microparticles but the problem is that the encapsulation efficiency very low.
My polymer is Ethylcelluose and my compound is soluble in both the aqueous phase and organic phase. I modified the pH of the aqueous phase (PVA) so my compound in this modified pH, and supposed to be not ionized at all as a procedure to decrease aqueous solubility. The drug to polymer ratio is 1:100 which is quite low, but this is my target.
Anita G Sullad
The problem in your preparation is the drug quantity is too low. Try double emulsion method. good luck
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Ahmad Mohamad Zaiter
I tried double emulsion but unfortunately low encapsulation efficiency compared to single emulsion method.
the drug is soluble in organic solvent but also soluble in aqueous phase !
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