Any suggestion to do solubility study for a compound that I have a very small amount of it and I want to test its solubility in different solvents.
What do you mean "a very small amount" ?...100 mg, 10 mg or 1 mg? I would like to recommend you a book "Mircoscale Organic Laboratory" D.W.Mayo, R.M.Pike, D.C.Forbes, Wiley, 2011. You will find there a lot of techniques dealing with a small quantities of materials. I usually perform such tests in small vials ( 5mm width-5cm lenght). After test I evaporate solvent (sand bath or hair dryer) and do next test with another solvent.
Greatings,
AD
What do you mean "a very small amount" ?...100 mg, 10 mg or 1 mg? I would like to recommend you a book "Mircoscale Organic Laboratory" D.W.Mayo, R.M.Pike, D.C.Forbes, Wiley, 2011. You will find there a lot of techniques dealing with a small quantities of materials. I usually perform such tests in small vials ( 5mm width-5cm lenght). After test I evaporate solvent (sand bath or hair dryer) and do next test with another solvent.
Greatings,
AD
It is about 50 mg but this 50 mg will undergo to be tested by at least 4 solvents.
thank u very much Dr. Andrzej Danel.
Yes..you can do solubility study in vial...But question is have you having standard analytical method data for drug estimation?
If we discussing an official guideline to conduct solubility studies for APIs I suggest to check the European Pharmacopoeia or US Pharmacopoeia but I am not sure if you will find there a method suitable to test small quantities of compounds.
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