What is the values in terms of energy of electrostatic intrctns, van der Waals intrctns, H-bond, hydrophobic intrctns in protein-ligand binding?

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Yuri Mirgorod

Debanjan Saha

To obtain the values of interactions, data on a specific protein and ligand are required. Therefore, the listed interactions can be arranged in descending order of interaction energy. Electrostatic, hydrophobic interactions, hydrogen bond, van der Waals interactions. Electrostatic interactions are ionic interactions with ionic bonds. They compete with covalent bonds in terms of bond energy. The remaining interactions are intermolecular. They are an order of magnitude less in energy than electrostatic interactions. Hydrophobic interaction is very complex in nature. Read about modern ideas about it in the articles

Preprint Nuclear quantum effect in aqueous micellar surfactant solutions

Article Relationship between Classical and Quantum Mechanics in Mice...

Thanks a lot, Yuri Mirgorod for the explanation.