I was studying about ppi prediction with machine learning approach, then the latest development I've found reported 97% accuracy with DVM hereArticle Accurate prediction of protein-protein interactions by integ...
.Do you know is there any more progression in this topic?
You can try STRING which is a database of known and predicted protein-protein interactions . The interactions are annotated with confidence scores. They are indicators of how likely STRING judges an interaction to be true, given the available evidence.
Good Luck
Models work better for some classes than others. Many protein interactions are mediated by common, well-characterized domain families, such as SH2, SH3, and PDZ. It's fairly easy to recognize receptor domains and ligand sequences for these interactions. For example: Article A map of WW domain family interactions
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