Does anybody know in current clinical practice, what is the therapeutic option for EGFR mutation NSCLC patients who develop acquired resistance to first-line EGFR inhibitor but do not have T790M mutation? Are chemo, radiation, or even surgery still feasible? Thank you.
Dear Sir,
according to his symptoms and number and sites of progressive lesions.
If he is asymptomatic or he has symptoms with single lesion, you can add local therapy like radiotherapy plus to continue on EGFR inhibitors.
if he is symptomatic with multiple lesions, you have to give systemic chemotherapy plus or minus immunotherapy according to PD-L1 status.
Thanks
Thank you Saad and Amr!
Amr, a followup question: do those relapsed patients actually respond to chemo after being resistant to EGFR inhibitors? especially for those whose resistance is not due to T790M mutation. They might be generally resistant to treatment, aren't they? I only though about chemo first, and if resistance occurs you can switch to EGFR inhibitors, but never thought that the other way around could also work.
- Badges
- Science topic
- Similar topics
- Linguistics
- Composition Studies
- Publication