Do you think that triple negative breast cancers are so since the beginning or can be the extreme grade of anaplastic evolution of cancers that at its beginning had some kind of hormonal receptors?
I am sure that that the flexibility of cells undergoing carcinogenic transformation allows many combinations of how features are "collected". TNB status may be acquired fast (from the beginning) or slowly. IHC of tumors for TN-markers suggests heterogenuity of cells regardin expression of the markers. Thus, I would say that both options in your question may have place.
The speed of getting TNegativity is only about acquisition of additional features to become more transformed. I believe, and have seen by proteomics of tumors, that on the molecular level we may have certainly more than 20-50 profile. The number would depend on how much of individual/specific for each patient features are included in definition of a profile.
With best regards,
Serhiy Souchelnytskyi
Dear Serhiy,
Thanks so much for your answer.
My point of view is the one of a radiologist whose daily experience brings slow growing cancer (usually with some hormonal receptor and with better prognosis) with mammographyc, echographic and MRI features so different from the ones fast growing and with worst prognosis (triple negative usually).
And in imaging we usually see that the formers are more tipical of 'fat breast', while the latter are more tipical in very 'dense' breasts.
Dear Sir,
Most triple-negative breast cancers have a basal-like cell pattern that line the breast ducts. Basal-like breast cancers tend to overexpress, or make too much of, certain genes that encourage cancer growth like BRCA1 & BRCA2.
If person born with BRCA mutation are increaced risk of developing many cancer. But mutation in BRCA1 gene will having a higher risk of developing basal like breast cancer.
I think overexpression of BRCA1 (Not BRCA2) will more likly to direct TNB.
Please guide me if I am wrong. I am also working on Expression analysis of Breast Cancer MicroRNA.
Thank you,
Maulik
Molecular sub classification of TN breast cancer by gene expression profiling with a specific focus on genomewide studies may reveal the molecular significance of the TNBC
Maulik,
Basal-like breast cancers do not over-express BRCA1. BRCA1-associated breast cancers mostly fall into the basal-like category, but they have a mutated BRCA1. These mutations often lead to no BRCA1 protein being expressed (even in the presence of mRNA).
TNBC at now divided into 6 groups and permit to our policy for better and specific treatment them
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