Lysophosphatidic acid (LPA) is a phospholipid derivative that can act as a signaling molecule

LPA acts as a potent mitogen due to its activation of three high-affinity G-protein-coupled receptors called LPAR1, LPAR2, and LPAR3 (also known as EDG2, EDG4, and EDG7). Additional, newly identified LPA receptors include LPAR4 (P2RY9,GPR23), LPAR5 (GPR92) and LPAR6 (P2RY5,GPR87).

Because of its ability to stimulate cell proliferation, aberrant LPA-signaling has been linked to cancer in numerous ways. Dysregulation of autotaxin or the LPA receptors can lead to hyperproliferation, which may contribute to oncogenesis and metastasis.

LPA may be the cause of pruritus (itching) in individuals with cholestatic (impaired bile flow) diseases.

Hi,

thanks for your answer, but I asked for lysoBISphosphatidic acid, also known as bis(monoacylglycero)phosphate...

It regulate cholesterol transport (lysobisphosphatidic acid-rich membranes contained within multivesicular late endosomes regulates cholesterol transport, presumably by acting as a collection and distribution device).

If you have been unable to find anything in Medline, there are a few things you should consider.

A) Are you sure it is secreted into the plasma?

1) Plasma contains a large number of factors that are not _secreted_ into plasma, e.g. alanine and aspartate aminotransferases and other stuff that get released into the plasma as a result of cell death and turnover.

2) As a lipid, it might just be part of the lipoprotein-mediated transport of other lipids incl. cholesterol, particularly since it has a role in multivesicular bodies like Dr. Sinishaw already said.

B) Even if it is secreted by the cells, is there a reason to think that is has or might have a signalling role in the plasma? It might e.g. act as paracrine or autocrine regulator and end up in plasma as a means of clearance.  If the answer is yes, and you cannot find any data, I guess it is time you start formulating experiments.

LPA is the bioactive phospholipid, produced by the enzymatic action of autotaxin/enpp2 in the extracellular spaces, where it involves in the number of signaling pathways via LPA-G-protein coupled receptor. It has the crucial role in the organisms initial development. Also its aberrant signaling involves in various human diseases including cancer. It enhances cellular proliferation and making tumor aggressive in nature. Its signaling increases local invasiveness of tumor cells and plays role in the metastasis process also.