What is the relation between association analysis and analysis of population structure (Using STRUCTURE software)?

20 January 2014 1 10K Report

I have a population that consists of 187 lines. I genotyped them using 156 SNPs. This population were derived from crossing between 11 parents (from different regions). The 187 are highly homozygous line (F11). I was informed that it would be incorrect if I analyzed this population using STRUCTURE software. Why is this?

Priyanka Siwach

Basically you have generated RILs and want to apply population statistics, which is not right. You have narrowed the genetic base which will lead to biased population structure. Rather you should have taken random population representing a wider genomic base. STRUCTURE software is used when we take population studies

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