Is there any difference of rate of h.pylori infection in patients with different severity of gastritis?
- Mild gastritis, acute gastritis or chronic gastritis - 100% infection rate
- non-ulcer dyspepsia - 30-60% infection rate
- peptic ulcer - 85-95%
- intestinal metaplasia - 50%
- MALT - ~100%
- Gastric cancer - 60-80%
some references:
Dunn, B. E., H. Cohen, and M. J. Blaser. 1997. Helicobacter pylori. Clin. Microbiol. Rev. 10:720-741.
Kusters, J. G., A. H. van Vliet, and E. J. Kuipers. 2006. Pathogenesis of Helicobacter pylori infection. Clin. Microbiol. Rev. 19:449-490.
I do not think that there is a different rate of infection among the different type of gastritis, H. pylori is found in all cases of gastritis (when diagnosed by histology). The different degrees of inflammation may be due to differences in strains (cagA positive or negative) or bacterial load or host immune response. Also when we find this organism in dyspepsia or peptic ulcer, it is observed in inflamed gastric mucosa and not in the ulcerative lesion. The same is for intestinal metaplasia and cancer (H. pylori is not present in metaplastic or neoplastic tissue, but in surrounding areas). On the other hand, all these conditions are strongly and evidence-based related to H. pylori.
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