Does anyone knows software to do epistasis analysis for pairwise interactions between two sets of snps?

I need to do epistasis analysis between two sets of SNPs (each contains ~1000 SNPs). I am interested in pairwise interactions between the SNPs on different sets and not between SNPs on same set. I...

08 September 2015 2,648 2 View

Does visualising your continuous data using bar graph makes any sense?

03 April 2015 1,401 11 View

Which allele should be used as a reference if the major allele is not the ancestral allele?

11 December 2014 8,472 4 View

Does anyone know any software or R package to visualize SNPs on chromosomes?

Recently I was trying to visualize the GWAS significant SNPs on chromosome to get a global view and to look for any clustering of significant SNPs in any region of chromosome. I found a software...

11 December 2014 4,661 6 View

How do you know if the SNP is situated in an miRNA coding sequence?

Is there a way to find out if a SNP is located in an miRNA coding region? For example, if I have a list of SNPs, is it possible to find out how many of my SNPs are located in an miRNA coding...

11 December 2014 7,455 8 View

What is the maximum length of upstream promoter sequence of genes in homosapiens?

11 December 2014 8,560 6 View

Regression between a continuous outcome and a categorical (ordinal) predictor ?

Here the outcome variable is continuous and bi-modally distributed with clustering at the both extreme ends of histogram. The predictor is a categorical variable which has three categories such as...

10 November 2014 3,749 5 View

How can I create a UCSC BED file from plink data?

I know that the bed file (Binary ped) of plink is different from UCSC's bed file. I would like to create a bed file of genomic co-ordinates of all the SNPs in plink data. Can any one help me with...

06 July 2014 1,341 8 View

How to deal with data with double the number of cases than controls?

Lets say I am analyzing a genetic polymorphism data where I have genotyped 120 cases and 50 controls. I guess it is not statistically right to compare a larger number of cases to fewer controls as...

05 June 2014 9,106 8 View

How to calclulate sample size for studying epistasis between two SNPs ?

Can anyone suggest a method to calculate a sample size to study an effect of epistasis between two polymorphisms over a clinical phenotype (ex: drug response). Suggestion of any reference will be...

05 June 2014 4,741 2 View

How to compare two groups with only two measurements?

Hiiiii everyone! I have an enquiry on statistical analysis. I was looking for many forum and it's still cannot solve my problem. I want to compare means of two groups of data but only with two...

03 March 2021 8,796 3 View

Enhanced Yellow Fluorescent Protein (Aequorea victoria) DNA sequence?

I am on the lookout for the Enhanced Yellow Fluorescent Protein (Aequorea victoria) DNA sequence. Does anyone know where I can find it? Thank you in advance

03 March 2021 3,568 1 View

What kind of fluid could I use for a pitfall trap that also does not invalidate molecular testing?

Hi, I want to start testing pitfall trap to obtain ants samples, but I need to conduct molecular analysis on those insects. So, what kind of fluid can I use? Ethanol expires too early and I need...

03 March 2021 5,978 5 View

Can linear DNA be used as template for site-directed mutagenesis?

Is it possible to induce site-directed substitution mutation by quick-change method on linear dsDNA? or it has to be cloned in some vector? If yes, should it be treated with the Dpn1 enzyme...

03 March 2021 401 4 View

What's the best way to measure growth rates in House sparrow chicks from day 2 to day 10?

What's the best way to measure growth rates in House sparrow chicks from day 2 to day 10? Since, the growth curve from day 2 to 10 won't be like the "Logistic curve" it might not follow logistic...

03 March 2021 1,401 3 View

Do we need to write protocol for a second study of a systematic review that has been registered and published?

I have conducted and published a systematic review and meta-analysis research with the topic related to public health and health pomotion (protocol was registed in PROSPERO). Now we want to...

03 March 2021 8,920 3 View

How to increase a model accuracy ?

dear community, my model is based feature extraction from non stationary signals using discrete Wavelet Transform and then using statistical features then machine learning classifiers in order to...

03 March 2021 6,994 5 View

Do I need to do linear regression before running mediation analysis using PROCESS MACRO by Hayes ?

I just wanted to check if I need to run a linear regression separately if I am using PROCESS MACRO to run mediation analysis. Thank you.

02 March 2021 4,359 3 View

Sample dilution for quantitative analysis using ELISA?

If the detection range is in ng/ml but the reference range is in ug/ml for a molecule or protein in serum or plasma .how to dilute and what is the initial volume to be taken for quantitative analysis

02 March 2021 7,670 3 View

Is There Any Feasible Method To Test Fluorescent Compounds Other Than Fluorescence Spectrometers ??

Is There Any Feasible Method To Test The Efficiency Of Fluorescent Compounds Other Than UV Spectrometers ? Suggestions Would Be Appreciated !

02 March 2021 5,785 3 View