A preliminary demonstrated that I could not find any specific diseases that nitric oxide and S-Nitrosothiols are really good predictors for.
Diseases such as alzheimer's are so big that i doubt providing clinicians with a quantitative skin-nitric oxide/ S-Nitrosothiol level would be relevant.
Thank you!
Chithan C Kandaswami
Nitric oxide was identified as EDRF (endothelium derived relaxation factor) in 1980, using aortic rings. This establishes a link between NO and endothelial damage (impaired vasodilation). A gradient of the NO synthesizing enzyme, endothelial nitric oxide synthase (eNOS), has been detected in the aorta, which correlates with the gradient of lesions (endothelial damage). Endothelial damage and atherosclerosis are, therefore, linked with NO.
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